Since Luo Jin’s parents are so supportive, Yang Ping decided to go all out and take a gamble.
In Luo Jin’s current situation, there’s no way to think in conventional terms; without treatnt, there is no chance at all, but with treatnt, there is a sliver of hope, so there’s no need to consider any risk—just go straight for the new K virus therapy.
However, the dosage needs to be calculated precisely to avoid another accident like Sisi’s.
With the experience from Sisi, Yang Ping already has a rough understanding of the dosage. After the experintal team studied Sisi’s treatnt data, they gained so insights, which are just right to be applied to Luo Jin.
In fact, the data obtained from these real-world battles are the most precious, more aningful than the data obtained from routine clinical trials, because they co directly from the accumulation of treatnt experience in clinical trials, closely resembling real clinical practice.
The dose for Luo Jin this ti is one-fifth of what was given to Sisi, adopting a thod of gradually increasing the dose, treating while observing. If the effect is not satisfactory, gradually increase the dose to avoid severe intracranial brain tissue edema due to rapid tumor cell death, as the side effects that appeared on Sisi must not occur again.
After injecting the K biological agent, Luo Jin developed a low fever, which is an expected immune response. Compared to Sisi’s previous reaction, it is already considered mild. It shows how much Sisi contributed to this experint. It is not an exaggeration to say that without Sisi’s experint, obtaining these valuable data through routine clinical steps would have taken much longer.
Apart from the low fever, Luo Jin did not experience any other complications. On the fourth day, Luo Jin’s temperature returned to normal, marking that the immune-related side effects had been overco. Next, it’s about how the edema caused by tumor cell death develops intracranially.
Whether this one-fifth dose is far from sufficient or even excessive, whether the first dose being insufficient will cause immune resistance, thus interfering with subsequent treatnts, are unsolved questions that need to be answered with Luo Jin.
On the fifth day, Luo Jin exhibited seizure symptoms, which is a new discovery. It had never appeared in Sisi. The so-called seizure is actually caused by abnormal discharges in the brain, indicating that abnormal discharges have appeared inside Luo Jin’s brain.
Where did these abnormal discharges co from? Could the brain tissue have ford scars so quickly? Impossible, it can’t happen so fast.
If no scars have ford, then possibly granulation tissue as the precursor to scar formation, which can also cause seizures.
Now, regarding life, these are minor issues. The clinical doctors involved in the experint thought back to their successful rescue of a rabies patient before, implenting brain hibernation for Luo Jin to mitigate damage to brain cells from brain tissue edema.
In theory, all this is impeccable, but whether it can be effective is currently unknown.
Luo Jin’s brainstem respiratory center is in a suppressed state; even slight edema during treatnt may cause a halt in breathing. This is different from Sisi, who did not have such severe respiratory suppression before treatnt.
A high-definition screen was erected in the ICU office, where various data from all around are gathered. Yang Ping monitored the various data on the screen, hoping to uncover potential internal connections and make so predictions about the trend of the illness.
"Will the seizures be a problem?" the ICU director asked.
"Actually, the current treatnt is sowhat similar to our previous rescue of a rabies patient. However, the current treatnt does not damage brain cells as severely as the rabies virus. Our K virus now will kill tumor cells without affecting normal cells, but the death of tumor cells brings a series of issues, such as edema. We use the hibernation therapy to temporarily put the brain into a dormant state. This is an excellent thod to help the brain get through this dangerous period, but how is it causing seizures? What precisely causes the abnormal discharge of brain cells?" Yang Ping said to himself.
Everyone listened attentively beside him. Professor Yang’s analysis of the illness always resembled peeling away layers, with the entire reasoning process watertight.
"Although regarding lifesaving, these symptoms are trivial and do not cause life-threatening risks, we must find the cause to avoid leaving a permanent seizure after treatnt."
"Could it be that the tumor cells are absorbing slowly, forming fresh granulation in the brain tissue?" Song Zimo asked.
"This is possible. This situation did not occur in Sisi but appeared in Luo Jin. Sisi is an adolescent, Luo Jin an adult. Sisi’s tissue repair ability is stronger than Luo Jin’s. Even with the sa necrosis of tumor cells, Sisi would not form granulation, but Luo Jin might? This could be speculated, but why did Sisi exhibit enhanced mory after treatnt? Is there any relation between the two? Is mory enhancent due to strengthened neuronal synaptic connections between brain cells?" Yang Ping questioned a series of issues.
There were too many questions here; grabbing any handful would yield a bunch. He wanted to clarify each problem.
"Our animal experints did not focus on these contents. In the future, animal experints should include studies on the impact of treatnt on neuronal synaptic connections in brain cells, the pathological process of tumor cell absorption in brain tissue, and so on."
"Got it, making a note of it!"
Tang Shun and Lu Xiaolu imdiately jotted it down. With Professor Yang’s prompt, they seed to discover that this topic could be expanded, deriving many sub-topics.
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