Chapter 1529: Chapter 1135: The Collapsed Phone_2
The lab test results were also reviewed by Yang Ping: white blood cells 12.60×10^9/L; red blood cells 4.62×10^12/L; hemoglobin 125.00 g/L; platelets: 187.00×10^9/L; neutrophils percentage 89.70%; lymphocytes percentage 2.90%; monocytes percentage 7.30%; erythrocyte sedintation rate 18 mm/1 h; prothrombin ti 15.4 s; prothrombin standard ratio 1.38; activated partial thromboplastin ti 19.6 s; thrombin ti 11.5 s; alanine aminotransferase 12U/L; aspartate aminotransferase 21 U/L; AST/ALT ratio 1.62; total bilirubin 17.0μmol/L; direct bilirubin 7.9μmol/L; indirect bilirubin 9.6μmol/L; total protein 67.8 g/L; albumin 42.5 g/L; globulin 25.3 g/L; potassium 3.21 mmol/L; sodium 132.0 mmol/L; creatine kinase 640 U/L; creatine kinase MB 30 U/L; lactate dehydrogenase 340 U/L.
Imaging examination: CT (brain plain scan) suggests slight widening of cerebral gyri and narrowing of sulci, likely indicating brain edema. MRI (brain plain scan magnetic susceptibility imaging) suggests a slightly high signal shadow in the T2 fluid-attenuated inversion recovery sequence of the right parietal lobe’s sulcus, possibly indicating ningitis changes based on dical history.
Compiling these test results, Yang Ping can now fully ascertain that his judgnt is accurate; how could a hereditary disease cause a fever? So, he still considers it an infectious disease, just that the pathogen hasn’t been identified yet.
At the ti, this central nervous system infection presented atypically and was at an early stage, thus easily masked by seizures. Now, central nervous system infection symptoms are very apparent, allowing for diagnosis based on clinical symptoms even without pathogen evidence.
Back then, treating as primary amoebic ningoencephalitis was the correct course of action. If they hadn’t seized those two days, the patient’s mortality rate would have been 97%.
Therefore, regardless of whether it’s amoebic infection now, it definitely needs to be treated as such. Even if it’s wrong, it’s not a big deal, but missing the treatnt window would be a cause for regret.
“Continue with empirical treatnt.” Yang Ping gave his opinion.
Anti-amoebic treatnt has only been administered for two days; it’s impossible to gauge its effectiveness yet,
Regarding his seizure symptoms resembling those in his maternal grandfather’s family, they should be managed symptomatically until results are in; there’s a prioritization issue here, and now we grasp the urgent and crucial.
Director Xu, with Professor Yang’s support, beca a lot braver; now, besides symptomatic treatnt, she’s treating it fully as amoebic ningoencephalitis, continuing the original treatnt plan. Using such empirical treatnt in this situation requires enough courage and understanding from the family.
In dicine, many tis it’s not about intentions; no matter your starting point, with this result, you bear responsibility.
Fortunately, the patient’s family is quite understanding and trusts Sanbo Hospital. His parents agreed with Director Xu’s treatnt plan, and with Yang Ping’s support, Director Xu faced no obstacles.
In the afternoon, Director Xu called again, unusually excited, telling Yang Ping: brain fluid examination under low magnification found amoeba-like motile entities; switching to high magnification, several actively moving pseudopodia of trophozoites were observed; covering with a coverslip, cedar oil was added, and under oil imrsion, wet slides showed clearly amoebic trophozoites extending pseudopodia and endoplasmic flow motion. Trophozoites asured approximately 10~35μm, oval, elongated or irregular shapes, cytoplasm with vacuoles or contractile vacuoles and varying-sized granules, a single visible nucleus with a prominent nucleolus and no chromatic grains.
Director Xu breathlessly reported the brain fluid sar results over the phone, affirming that the empirical choice of dication was correct; otherwise, this patient would likely have missed the best treatnt window and died.
Now given the most suitable dication at the optimal ti, the patient indeed might survive.
On the fifth day post-treatnt, the patient’s condition began improving, and other symptoms were alleviated, except seizures continued.
Yang Ping organized this case in his mind, becoming clearer; his hypothesis wasn’t wrong. It was a case that couldn’t be explained by a monism theory because it combined a rare hereditary disease and primary amoebic ningoencephalitis. Initially, the hereditary disease manifested, followed gradually by the amoebic ningoencephalitis symptoms, intertwining two rare diseases at an extrely low probability, leaving even experienced doctors baffled.
A week later, aside from continued seizures, other symptoms had vanished, making him one of the rare survivors of primary amoebic ningoencephalitis.
—
At the Institute, the second treatnt for Sisi, Luo Jin, and Ning Yu comnced. With previous experiences accumulated, Yang Ping now decided to start treatnt for all three simultaneously.
This second treatnt was approached very conservatively by Yang Ping concerning dosage. Due to past experiences, the theoretical dosage was further reduced to ensure safety. Since the condition is now controlled, there’s no need to be overly aggressive.
This treatnt was very mild; Sisi didn’t even experience a low fever and, with the injection of K virus, it was like a normal dication drip. Yang Ping suspected this adenovirus-templated biological preparation might possess self-adaptive capacity similar to viruses, capable of in vivo iterative mutation.
These occurrences were noted in previous trials; the first trial had good outcos, but the second had very poor results because the virus had completed in vivo iteration and mutation—it enhanced so capabilities while weakening others, prompting the subsequent modification of biological preparations.
Through the second treatnt, Sisi cleared a significant amount of the virus again. Luo Jin’s treatnt started later, so his progress wasn’t as fast as Sisi’s. anwhile, Ning Yu’s condition was the lightest; since he was admitted for treatnt at the earliest sign of a recurrence, after two treatnts, tests showed his tumor cells were cleared entirely.
Ning Yu beca the first patient cured with this new therapy; his na will be recorded in dical history books.
Individual case reports on these three cases were published in the “dical” Journal, causing a sensation and a global frenzy. Various language versions of the “dical” Journal were rapidly disseminated, with people eagerly buying them. Even non-dical professionals and researchers joined the rush to purchase the “dical” Journal.
The phones at Sanbo Research Institute rang off the hook daily, with inquiries from patients or relatives about the new therapy. With no alternative, the institute’s doctors resorted to picking up the phone and leaving it on the desk.
When Yang Ping introduced the Spatial Orientation Gene Theory, it only stirred the dical academic community; ordinary people had no interest in such advanced dical theory.
Yet this ti is different. The clinical treatnt papers on the K virus have taken the spotlight like a whirlwind, thrilling global tumor patients and their families—now they see hope.
“Professor? What to do? Never expected a single paper to have such a sensational effect,”
Tang Shun expressed helplessly.
Yang Ping glanced at the phone resting on the desk, a wry smile creeping up, as now all phones at the institute were like this. Beyond ergency internal calls, any phone capable of connecting to external lines would remain engaged all day and night until it lted down.
Even Yang Ping’s office phone wasn’t spared; who knows where these people got the number.
Several doctors’ private phones also started to succumb because when calls couldn’t get through, people sohow obtained the doctors’ private phone numbers and directly called them. The doctors had no choice but to turn off their phones; communication between diagnosis and treatnt across departnts depended on shouting while cross-departnt communication relied on the hospital’s internal phones.
“Things should calm down a bit later!” Even Yang Ping was at a loss.
Lu Xiaolu asked, “How do they even know our phone numbers?”
Tang Shun chuckled, “As long as there’s enough market demand, soone will undoubtedly make it happen.”
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