Surgery Godfather Chapter 1902: 1314: Dialogue with the Body

Capítulo 1902: Chapter 1314: Dialogue with the Body

The regulation theory in the “Inner Canon of Huangdi” is undoubtedly advanced, but Yang Ping’s theory is rely a hypothesis, and verifying it through experints is no easy task. His K Therapy is a practical application of this hypothetical theory, but treating only a few types of tumors is not enough to demonstrate the universality of this theory.

Yang Ping decided to apply this theory to other non-tumor patients, but doing so is not simple. It requires integrating and communicating with so existing dical theories of the disease, so the case selection for non-tumor patients is extrely strict.

Professor Manstein made a call from Berlin.

“Professor, I may have found the best case to validate your theory.” Manstein spoke solemnly on the other end, “A 27-year-old woman with Lynch Syndro.”

Yang Ping imdiately sat up straight. Lynch Syndro—hereditary non-polyposis colorectal cancer syndro. The patient carries a germline mutation in DNA mismatch repair genes, with a lifeti risk of developing colorectal cancer, endotrial cancer, stomach cancer, and other cancers being very high. It is a disease that is flawed at the systemic level: the DNA repair capacity of cells throughout the body is inherently insufficient, leading to the accumulation of mutations and eventually cancer.

Indeed, this was an excellent case.

“She hasn’t developed cancer yet,” Manstein continued, “but genetic testing shows she carries a pathogenic mutation in the MSH2 gene; colonoscopy revealed dozens of adenomatous polyps, and gastroscopy showed early atrophic gastritis with intestinal taplasia, all are precancerous lesions. According to standard guidelines, she should imdiately undergo prophylactic total colon resection and regular endoscopic monitoring.”

“But she refused surgery,” Yang Ping guessed, “wants to try a new approach?”

Manstein retrieved the patient’s complete dical records, “She is a violinist who just signed with a top European symphony orchestra. Surgery and subsequent recovery would severely impact her career. More importantly…” he paused, “she heard your theory and wants to try, even if it fails, she doesn’t mind. It’s not too late to consider traditional therapy then.”

“Does she want to try the application of K Therapy to other diseases?” Yang Ping asked.

“Yes, she wants to try the ‘regulate systems, prevent errors’ approach you ntioned in your paper.” Manstein’s pace quickened, “She has read all your articles in the ‘dical’ journal, including that philosophical paper. She said: ‘If you have truly found a way to communicate with the body, I want to be that communicator.’

Yang Ping paused for a mont: “But K Factor is currently only used for confird cancers, specifically targeting tumors overexpressing TIM. Her situation is not very suitable; pursuing treatnt would be purely experintal.”

“Her colon polyp biopsy shows that all adenoma cells abnormally overexpress mbers of the TIM-F family, and the expression pattern is very unstable; so cells express highly, so express lowly, precisely what you described as ‘identity system instability.'” Manstein retrieved single-cell sequencing data, “More crucially, her normal colonic mucosal cells also significantly overexpress TIM compared to healthy people, with fluctuating levels.”

Yang Ping’s eyes brightened: “Does this an her entire colonic epithelial cell identity system is in an unstable state?”

“Our preliminary thinking is so; DNA repair defects leading to mutation accumulation may interfere with the expression regulation of genes related to cell identity maintenance, causing TIM system disorder. A disordered system is more easily hijacked, like a building with a flawed security system, more easily occupied illegally.”

“So you think,” Yang Ping analyzed quickly, “if we can regulate this unstable identity system before cancer occurs, restore its stability, perhaps we can prevent cancer and cure this disease.”

“That’s what she wants to validate.” Manstein nodded, “And she is willing to be part of this experint, with regular biopsies, blood monitoring, comprehensive multi-omics analysis, even implantable sensors to monitor local microenvironnt changes.”

Yang Ping took a deep breath. This was an unprecedented challenge: using regulatory thods to intervene in a pre-cancerous state, the goal being prevention rather than treatnt; the patient is young, lacks the urgency of late-stage cancer patients, but has higher demands, needing not only effectiveness but also no impact on normal life and work.

However, this disease is indeed very suitable for expanding K Therapy beyond tumors, as it currently lies in the interdiate state between tumor and non-tumor. If successful, it will pave the way for advancing K Therapy into non-tumor fields.

“I need to discuss with the team,” Yang Ping said, “This is a perfect validation case; if regulation can truly prevent cancer occurrence, then it will be more significant than treating already ford cancer, and further confirm my hypothesis is correct.”

“I will bring her to Nandu in three days,” Manstein said, “Her na is Alina Volkova, Russian-German. By the way, she is also a molecular biology doctor, researching cell fate determination, so she fully understands the risks and uncertainties involved.”

After hanging up, Yang Ping sat quietly in the office for ten minutes.

Then he opened the “Inner Canon of Huangdi,” flipping to “Su Wen·Four Qi Adjusting God Great Discussion”: “Therefore, the sage does not treat already ill but treats the not yet ill, does not treat already chaotic but treats the not yet chaotic… Only when the illness is already ford then prescribe dicine, only when chaos has already ford then govern, this is like being thirsty and then digging a well, fighting and then casting a weapon, is it not too late?”

Words from two thousand years ago, read at this mont weigh a thousand pounds, the theory revealed within is so advanced, perfectly aligning with his discovered hypothesis.